Publicaciones Científicas

Descripción del proyecto


Fernández, Eduardo Aguilar, and Ana Maricela Carballo Alfaro. "Proteína C reactiva, síndrome metabólico y riesgo cardiovascular en la población costarricense nacida entre 1945 y 1955." UNED Research Journal 12.1 (2020): e2662-e2662.

Fernández, Eduardo Aguilar, and Ana Maricela Carballo-Alfaro. "Factores asociados a la Proteína C reactiva en la población costarricense nacida entre 1945 y 1955." Población y Salud en Mesoamérica (2020).


Santamaría-Ulloa, Carolina, Melina Montero-López, and Luis Rosero-Bixby. "Diabetes epidemics: inequalities increase the burden on the healthcare system." Health policy and planning 34.Supplement_2 (2019): ii45-ii55.

Picado-Ovares, José E., et al. "Adverse outcomes of frailty in the older population of Costa Rica." Acta Médica Costarricense 61.4 (2019): 166-171.

Santamaría-Ulloa, Carolina, and Cindy Valverde-Manzanares. "Inequality in the incidence of cervical cancer: Costa Rica 1980–2010." Frontiers in Oncology 8 (2019): 664.

Rosero-Bixby, L., Rehkopf, D. H., Dow, W. H., Lin, J., Epel, E. S., Azofeifa, J., & Leal, A. (2019). Correlates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedures. PLoS ONE 14(10): e0223766.

Rehkopf, D. H., Duong, A., Dow, W. H., & Rosero-Bixby, L. (2019). Life Course Body Mass Index and Biomarkers in Persons 60 and Older: a Comparison of the United States and Costa Rica. Public health nutrition, 22(2), 314.

Rosero-Bixby, L.; Dow, W. H. & Brenes, G. (2019) Costa Rican Longevity and Healthy Aging Study.  En: Gu D., Dupre M. (eds) Encyclopedia of Gerontology and Population Aging. Springer Cham. Ebook.

Glei, D. A., Goldman, N., Ryff, C. D., & Weinstein, M. (2019). Physical function in US older adults compared with other populations: A multinational study. Journal of aging and health, 31(7), 1067-1084.

Gross, A. L., Kueider-Paisley, A. M., Sullivan, C., & Schretlen, D. (2019). Comparison of Approaches for Equating Different Versions of the MMSE Administered in 22 Studies. American journal of epidemiology, , kwz228,

Kaiser, M. (2019). Benford's Law As An Indicator Of Survey Reliability—Can We Trust Our Data?. Journal of Economic Surveys. Vol. 00, No. 0, pp. 1–17.

Bordaa, M. G., Patino-Hernandezb, D., Cano-Gutiérrezb, C. A., Celis-Preciadoe, C. A., & Pérez-Zepedab, M. U. (2019). Sarcopenia, lung disease and mortality: a secondary analysis of the CRELES study. Geriatr., Gerontol. Aging (Impr.), 13(1), 36-38.

Barboza‐Solís, C., Porras‐Chaverri, M., & Fantin, R. (2019). Is tooth loss important when evaluating perceived general health? Findings from a nationally representative study of Costa Rican adults. Community dentistry and oral epidemiology.

Gutiérrez-Robledo, L. M., García-Chanes, R. E., & Pérez-Zepeda, M. U. (2019). Allostatic Load as a Biological Substrate to Intrinsic Capacity: A Secondary Analysis of Creles. The journal of nutrition, health & aging, 1-8.


Azofeifa, J., Ruiz‐Narváez, E. A., Leal, A., Gerlovin, H., & Rosero‐Bixby, L. (2018). Amerindian ancestry and extended longevity in Nicoya, Costa Rica. American Journal of Human Biology, 30(1), e23055.

Brenes-Camacho, G. (2018). Retirement decisions and family characteristics in Costa Rica. Revista Latinoamericana de Estudios de Familia, 10(1), 31-50.

Rosero-Bixby, L. (2018). High life expectancy and reversed socioeconomic gradients of elderly people in Mexico and Costa Rica. Demographic research, 38(3), 95-108.

Patel, P. C., & Devaraj, S. (2018). Height–income association in developing countries: Evidence from 14 countries. American Journal of Human Biology, 30(3), e23093.

Ovares, J. E. P., Calvo, I. C. B., Martínez, F. M., & Jirón, A. S. (2018). Frailty in the elderly population of Costa Rica. Japan Journal of Medicine. Jpn J Med, 1(5): 233 - 237 . doi: 10.31488/jjm.1000122.

Santamaría-Ulloa, C., & Valverde-Manzanares, C. (2018). Inequality in the Incidence of Cervical Cancer: Costa Rica 1980–2010. Frontiers in oncology, 8.

Glei, D. A., Goldman, N., & Weinstein, M. (2018). The Educational Gradient in Physiological Dysregulation: A Cross-Country. The Oxford Handbook of Integrative Health Science, 479.

Chanti-Ketterl, M., Gamaldo, A., Andel, R., & Thorpe Jr, R. J. (2018). The association between lipoproteins, disability, and physical function among older Costa Rican adults. Journal of aging and health, 30(5), 758-777.

Novak, B., & Lozano-Keymolen, D. (2018). Childhood disadvantages and the timing of the onset of natural menopause in Latin America and the Caribbean. Journal of women & aging, 30(4), 280-298.

Stringhini, S., Carmeli, C., Jokela, M., Avendaño, M., McCrory, C., d’Errico, A., ... & Delpierre, C. (2018). Socioeconomic status, non-communicable disease risk factors, and walking speed in older adults: multi-cohort population based study. bmj, 360, k1.

Fantin, R., Delpierre, C., Kelly‐Irving, M., & Barboza Solís, C. (2018). Early socioeconomic conditions and severe tooth loss in middle‐aged Costa Ricans. Community dentistry and oral epidemiology, 46(2), 178-184.

Sudharsanan, N., & Bloom, D. E. (2018). The demography of aging in low-and middle-income countries: chronological versus functional perspectives. In Future directions for the demography of aging: proceedings of a workshop, E-Book, The National Academies Press, Washington, DC, available at https://www. nap. edu/read/25064.


McEwen, L.M., Morin, A.M., Edgar, R.D., MacIsaac, J.L., Jones, M.J., Dow, W.H., Rosero-Bixby, L., Kobor, M.S. and Rehkopf, D.H. (2017). Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region. Epigenetics & Chromatin 10(1), 21. DOI: 10.1186/s13072-017-0128-2.

Payne, C., Chiu, C., Rosero-Bixby, L., Saito, Y., & Dow, W. H. (2017). Disability-Free Life Expectancy Among Older Adults In High Longevity Populations. Innovation in Aging, 1(Suppl 1), 1020.

Gertner, A. K., Domino, M. E., & Dow, W. H. (2017). Risk factors for late-life depression and correlates of antidepressant use in Costa Rica: Results from a nationally-representative longitudinal survey of older adults. Journal of affective disorders, 208

Yatsuya, H., Matsunaga, M., Li, Y., & Ota, A. (2017). Risk factor of cardiovascular disease among older individuals. Journal of atherosclerosis and thrombosis, 24(3), 258-261.

Glei, D. A., Goldman, N., Ryff, C. D., & Weinstein, M. (2017). Can we determine whether physical limitations are more prevalent in the US than in countries with comparable life expectancy?. SSM-population health, 3, 808-813.

Ramirez-Ulate, X., & Bolaños-Sanchez, M. (2017). Identification Of Factors That Influence Independence Of Costa Rican Nonagenarians And Centennials. Innovation in aging, 1(Suppl 1), 357.

Barboza C., Fantin R., (2017). The Role of Socioeconomic Position in Determining Tooth Loss in Elderly Costa Rican: Findings from the CRELES Cohort.-Int. J. Dental Sc., 19-3 (September-December): 79-94.

Celis Preciado, C. A., Borda, M., Patino-Hernandez, D., Cano, C., & Perez-Cepeda, M. (2017). Frailty And COPD Are Better Predictors Of Mortality Rather Than Each Entity Alone: A Secondary Analysis of the CRELES Study. American Journal of Respiratory and Critical Care Medicine 195: A2728.


Rosero-Bixby, L., & Dow, W. H. (2016). Exploring why Costa Rica outperforms the United States in life expectancy: A tale of two inequality gradients. Proceedings of the National Academy of Sciences of the United States of America, 113(5), 1130.

Rehkopf, D. H., Rosero-Bixby, L., & Dow, W. H. (2016). A cross-national comparison of 12 biomarkers finds no universal biomarkers of aging among individuals aged 60 and older. Vienna Yearbook of Population Research, 14, 255-277.

Rosero-Bixby, L., Coto-Yglesias, F., & Dow, W. H. (2016). Pulse blood pressure and cardiovascular mortality in a population-based cohort of elderly Costa Ricans. Journal of human hypertension, 30(9), 555.

Glei, D. A., Goldman, N., Risques, R. A., Rehkopf, D. H., Dow, W. H., Rosero-Bixby, L., & Weinstein, M. (2016). Predicting survival from telomere length versus conventional predictors: a multinational population-based cohort study. PLoS one, 11(4), e01524

Harhay, M. N., Harhay, M. O., Coto‐Yglesias, F., & Rosero Bixby, L. (2016). Altitude and regional gradients in chronic kidney disease prevalence in Costa Rica: Data from the Costa Rican Longevity and Healthy Aging Study. Tropical Medicine & International

Yang, F., Qian, D., & Hu, D. (2016). Prevalence, awareness, treatment, and control of hypertension in the older population: results from the multiple national studies on ageing. Journal of the American Society of Hypertension, 10(2), 140-148.

Andrade, F. C. D. (2016). Misreported diabetes: estimating the'real'burden of diabetes in Latin America and the Caribbean. Anais, 1-21.

Pérez-Zepeda, M. U., Cesari, M., & García-Peña, C. (2016). Predictive value of frailty indices for adverse outcomes in older adults. Revista de investigación clínica, 68(2), 92-98.

Villalobos-Cambronero, X., Kulzer-Homann, K., & Fernández-Rojas, X. (2016). Relación entre funcionalidad y caídas en la población adulta mayor del “Proyecto Costa Rica, Estudio Longitudinal de envejecimiento saludable”. Revista Hispanoamericana de Ciencia.

Goldman, N., Glei, D. A., & Weinstein, M. (2016). What matters most for predicting survival? A multinational population-based cohort study. PLoS One, 11(7), e0159273.


Payne, C. F. (2015). Aging in the Americas: Disability-free life expectancy among adults aged 65 and older in the United States, Costa Rica, Mexico, and Puerto Rico. The Journals of Gerontology: Series B, 73(2), 337-348.

Sánchez, M. B., & Guzman, F. H. (2015). Depresión en el adulto mayor costarricense y su relación con la autopercepción del estado de salud y desempeño funcional. Revista Clínica de la Escuela de Medicina de la Universidad de Costa Rica, 5(4), 78-87.

Rosero-Bixby, L., Modrek, S., Domino, M. E., & Dow, W. H. (2015). Aging and mental health in a longitudinal study of elderly Costa Ricans. Encyclopedia of Geropsychology, 1-11.

Blue, L., Goldman, N., & Rosero-Bixby, L. (2015). Disease and weight loss: a prospective study of middle-aged and older adults in Costa Rica and England. salud pública de méxico, 57, 312-319.

Reyes Fernández, B. R., Rosero-Bixby, L., & Koivumaa-Honkanen, H. (2015). Effects of self-rated health and self-rated economic situation on depressed Mood Via Life Satisfaction Among Older Adults in Costa Rica.Journal of aging and health, 0898264315589577


Jokela, M., Hamer, M., Singh-Manoux, A., Batty, G. D., & Kivimäki, M. (2014). Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies. Molecular psychiatry, 19(8), 910.

Jiménez-Fontana, P., & Corea, A. (2014). Stature prediction equations from the knee height for elderly in Costa Rica. Población y Salud en Mesoamérica, 12(1), 68-85.

Assari, S., & Moghani Lankarani, M. (2014). Association between heart disease and subjective health in ten north, middle, and South American countries. Int J Travel Med Glob Health, 2(4), 141-7.

Assari, S. (2014). Cross-country variation in additive effects of socio-economics, health behaviors, and comorbidities on subjective health of patients with diabetes. Journal of Diabetes & Metabolic Disorders, 13(1), 36.

Goldman, N., Glei, D. A., Rosero-Bixby, L., Chiou, S. T., & Weinstein, M. (2014). Performance-based measures of physical function as mortality predictors: Incremental value beyond self-reports. Demographic research, 30(7), 227.

Li, J., & Dow, W. H. (2014). The declining effect of sibling size on children’s education in Costa Rica. Demographic Research 31(48): 1431–1454.

Domino, M. E., Dow, W. H., & Coto-Yglesias, F. (2014). Educational gradients in psychotropic medication use among older adults in Costa Rica and the United States. Psychiatric services, 65(10), 1218-1225.

Rehkopf, D. H., Dow, W. H., Rosero-Bixby, L., Lin, J., Epel, E. S.,& Blackburn, E. H. (2014).Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: a population based observational study. American Journal of Human Biology, DOI: 10.1002/ajhb.22529

McEniry, M. (2014). Early Life Conditions and Rapid Demographic Changes in the Developing World. Consequences for Older Adult Health. Springer Science+Business Media Dordrecht. DOI: 10.1007/978-94-007-6979-3

Goldman, N; Glei, D; Rosero-Bixby, L.; Chiou, S; Weinstein, M. (2014).Performance –based measures of physical function as mortality predictors: Incremental value beyond self-reports. Demographic research 30 (7): 227-252.


Rosero-Bixby, L.; Dow, W. H. & Rehkopf, D. H. (2013). The Nicoya region of Costa Rica: A high longevity island for elderly males. Vienna Yearbook of Population Research 2013 (11): 109-136.

Rehkopf, D. H., Dow, W. H., Rosero-Bixby, L., Lin, J., Epel, E. S., & Blackburn, E. H. (2013).Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: A population-based study.Experimental Gerontology 48(11): 1266-1273. PMID: 23988653. DOI: 10.1016/j.exger.2013.08.005

Brenes-Camacho, G. (2013). Factores socioeconómicos asociados a la percepción de situación socioeconómica entre adultos mayores de dos países latinoamericanos. Revista de Ciencias Económicas, 31(1).

Aguilar Fernández, E., & Alfaro, A. M. C. (2012). Prevalencia de Hipercolesterolemia en adultos mayores de Costa Rica. Población y salud en Mesoamérica, 9(2), 1-10.

Brenes-Camacho Gilbert (2012). Analisis de secuencias en el estudio del envejecimiento;. En: Redondo N y Garay S (coord.) “El envejecimiento en América Latina: evidencia empírica y cuestiones metodológicas”.ALAP: Serie Investigaciones No. 13 Pp.171-189

Miranda, J. J.; Herrera, V. M.; Chirinos, J. A.; Gómez, L. F.; Perel, P.; Pichardo, R.; González, A.; Sánchez, J. R.; Ferreccio, C.; Aguilera, X.; Silva, E.; Oróstegui, M.; Medina, J.; Pérez, C. M.; Suárez, E.; Ortiz, A. P.; Rosero, L.; Schapochnik, N.; Ortiz, Z.; Ferrante, D.; Casas, J. P.; Bautista, L. E. (2013). Major Cardiovascular risk factors in Latin America: A comparison with the United States. The Latin American Consortium of Studies in Obesity (LASO). PLOS ONE 8(1): e54056


Rosero-Bixby, L. & Dow, W. H. (2012) Predicting mortality with biomarkers: a population-based prospective cohort study for elderly Costa Ricans. Population Health Metrics 10(1):11. PMID: 22694922.

Modrek, S.; Dow, W.; Rosero-Bixby, L. (2012) Long-Term Association Of Economic Inequality And Mortality In Adult Costa Ricans, Social Science & Medicine 74(2012): 158-166, doi: 10.1016/j.socscimed.2011.10.034


Brenes-Camacho,G. (2011). "Favourable changes in economic well-being and self-rated health among the elderly". Social Science & Medicine 72(8):1228-1235.


Goldman, N.; Turra, C.; Rosero-Bixby, L. ; Weir, D.; Crimmins, E. (2010) Do biological measures mediate the relationship between education and health: Acomparative study, Social Science & Medicine 72(2011): 307-315, doi:10.1016/j.socscimed.2010.11.004 li>

Gersten, O.; Dow, W.; Rosero-Bixby, L. (2010). Stressors over the life course and neuroendocrine system dysregulation in Costa Rica. Journal of Aging and Health, 28 de mayo. DOI: 10.1177/0898264310367516.

Rehkopf D, Dow WH, Rosero-Bixby L. (2010). Differences in the association of cardiovascular risk factors with education: a comparison of Costa Rica (CRELES) and the United States (NHANES). J Epidemiol Community Health, 64(9):821-8.


Brenes-Camacho, G. & Rosero-Bixby, L. (2009) Differentials by Socioeconomic Status and Institutional Characteristics in Preventive Service Utilization by Older Persons in Costa Rica. Journal of Aging and Health 21 (5): 730-758. DOI: 10.1177/0898264309338299

Rosero-Bixby, L. & Dow, W. H. (2009) Surprising SES gradients in mortality, health and biomarkers in a Latin American population of adults. Journal of Gerontology: Social Sciences, 101093/geronb/gbn04.

Rosero-Bixby L.; Brenes-Camacho G.; Mendez-Chacon E. (2009)."Obesidad, envejecimiento y mortalidad en Costa Rica" En: Pelaez E. (coord.). Sociedad y Adulto Mayor en America Latina. Estudios sobre Envejecimiento en la Region, Pp. 117-138. Rio de Janeiro, Brasil: ALAP Editor, UNFPA, 1a. Ed.

Herrera, V. M.; Casas, J. P.; Miranda, J. J.; Perel, P.; Pichardo, R.; Gonzalez, A.; Sanchez, J. R.; Ferreccio, C.; Aguilera, X.; Silva, E.; Orostegui, M.; Gomez, L. F.; Chirinos, J. A.; Medina, J.; Perez, C. M.; Suarez, E.; Ortiz, A. P.; Rosero-Bixby, L.; Schapochnik, N.; Ortiz, Z.; Ferrante, D.; Diaz, M.; Bautista, L. E. (2009). Interethnic differences in the accuracy of anthropometric indicators of obesity in screening for high risk of coronary heart disease. International Journal of Obesity, 33 (5): 568-576.

Bautista, L. E.; Casas, J. P.; Herrera, V. M.; Miranda, J. J.; Perel, P.; Pichardo, R.; Gonzalez, A.; Sanchez, J. R.; Ferreccio, C.; Aguilera, X.; Silva, E.; Orostegui, M.; Gomez, L. F.; Chirinos, J. A.; Medina, J.; Perez, C. M.; Suarez, E.; Ortiz, A. P.; Rosero-Bixby, L.; Schapochnik, N.; Ortiz, Z.; Ferrante, D. (2009). The Latin American consortium of studies in obesity (LASO). Obesity Reviews, 10 (3):364-370.


Brenes-Camacho G. (2008). Economic well-being among elderly couples in marriage and cohabitation in Mexico. Poblacion y Salud en Mesoamerica (Revista Electronica) 6(1).

Jimenez Herrera, L.; Fernandez Rojas, X.(2008) Caracterizacion del uso de medicamentos en personas adultas mayores, Costa Rica 2007. Revista costarricense de Salud Publica, Vol. 17(33): 47-55..

Brenes Camacho, G.; Rosero-Bixby, L. (2008). Metabolic control in a nationally representative diabetic elderly sample in Costa Rica : patients at community health centers vs. patients at other health care settings. BMC International Health and Human Rights. 8:5.

Mendez-Chacon, E.; Santamaria-Ulloa, C.; Rosero-Bixby, L. (2008). Factors associated with hypertension prevalence, unawareness and treatment among Costa Rican elderly. BMC Public Health. 8:275

Rosero-Bixby, L. (2008). The exceptionally high life expectancy of Costa Rican nonagenarians. Demography. 45(3): 673-691.

Rosero-Bixby L.; Brenes-Camacho G.; Méndez-Chacón E. (2008). Obesidad, envejecimiento y mortalidad en Costa Rica. Sociedad y Adulto Mayor en América Latina. Estudios sobre Envejecimiento en la Región, p. 117-138. Rio de Janeiro, Brasil: ALAP Editor, UNFPA


Benavides Varela, S.; Fornaguera Trias, J. (2007) Un metodo simple para la recoleccion, extraccion y medicion de catecolaminas en orina de adultos mayores. Acta Bioquimica Clinica Latinoamericana, 41 (4): 541-52. 2007.

Hidalgo-Cespedes, J., Rosero-Bixby, L., & Antich-Montero, D. (2007). Mejora de la calidad y disminucion de costos de censos y encuestas utilizando computadores de mano (PDA). Una aplicacion en Costa Rica. Poblacion y Salud en Mesoamerica (Revista electronica), 5(1).

Mendez Chacon, E., Rosero-Bixby, L., Fernandez Rojas, X., & Barrantes Jimenez, K. (2007). Comparacion de los resultados de pruebas de laboratorio seleccionadas de un estudio poblacional de adultos mayores de Costa Rica. Poblacion y Salud en Mesoamerica (Revista electronica), 5(1).

Mendez Chacon, E., & Rosero-Bixby, L. (2007). Prevalencia de hipertension en adultos mayores de Costa Rica. Poblacion y Salud en Mesoamerica (Revista electronica), 5(1).

Brenes-Camacho, G., & Rosero-Bixby, L. (2007).Diabetes mellitus en adultos mayores costarricenses. Poblacion y Salud en Mesoamerica (Revista electronica), 5(1).

Puga, D., Rosero-Bixby, L., Glaser, K., & Castro, T. (2007). Red social y salud del adulto mayor en perspectiva comparada: Costa Rica, España e Inglaterra. Poblacion y Salud en Mesoamerica (Revista electronica), 5(1).

Fernandez Rojas, X.; Mendez Chacon, E.(2007). Estilos de vida y factores de riesgo para la salud de las personas adultas mayores del proyecto CRELES- Costa Rica 2004-2006. Poblacion y Salud en Mesoamerica (Revista electronica), 5(1).